If you are seeking advice on how to build a blockchain with Python, this is the definitive guide to achieving your goal. You might also be willing to see the final code, which was posted to GitHub. If what you need is more of a beginner's guide, try going with this one.
I haven’t seen anyone do it, but it can be done. If you are very comfortable with Python, if you are very comfortable with HTTP rather than using something that most of the other people are using, then go ahead, feel free to do it.